New College of Florida
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Vanderbilt University
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Graduate Education
Doctor of Philosophy
Major in Chemistry
2016-2023
Degree Expected in 12-16-2023
Key Words: Post-Translational Modifications, Human Lenses, Aging, Age-Related Nuclear Cataracts, Solubility
Latest Manuscript
PTMs in aging lenses and age-related nuclear cataracts may cause a change in solubility of protein regions if not the entire proteins, which may make age-related aggregation more likely to occur.
Key Takeaways:
-Peptides are more likely to be modified with dehydroalanine (DHA) than dehydrobutyrine (DHB).
-Proteins with DHA and DHB are more likely to be among the urea-insoluble fractions.
-Non-modified counterpart peptide sequences are more likely to be in the water- or urea-soluble fractions depending on the sequence and protein.
-DHA- and DHB-modified peptides can display trends, such as DHA or DHB levels that increase with age-related nuclear cataracts only, age or age-related nuclear cataracts, or neither age nor age-related nuclear cataracts.